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KMID : 0361519950060010100
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Korean Journal of Psychopharmacology
1995 Volume.6 No. 1 p.100 ~ p.104
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An Open Trial of fluoxetine in the Treatment of Obsessive-Compulsive Disorder
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Abstract
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In a 12-week open trial, nine outpatients with obsessive-compulsive disorder(OCD) were treated with fluoxetine, a selective serotonin reuptake inhibitor. The overall clinical state was assessed every two weeks until the end of the 12 week using
the
Yale-Brown Obsessive Compulsive Scale(Y-BOCS), the Clinical Global Impression Scale(CGI) and Hamilton Depression Rating Scale(HAM-D). A significant improvement was found in the symptomatology of patients as measured on Y-BOCS, CGI and
HAM-D(p<0.01
respectively). These results reinforce the clinical efficacy of fluoxetine in OCD. However, double-blind clinical trials should be performed to further clarify the efficacy of fluoxetine in OCD.
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KEYWORD
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